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|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 39 30 30 30 7d |que_ID{Y|RB09000}|
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|000005c0| 20 53 63 68 6f 6f 6c 63 | 68 69 6c 64 72 65 6e 3a | Schoolc|hildren:|
|000005d0| 20 20 4e 6f 20 4c 6f 6e | 67 65 72 20 61 20 43 6f |  No Lon|ger a Co|
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|00000620| 6d 70 73 6f 6e 2c 20 4e | 42 7d 0d 0a 24 41 66 66 |mpson, N|B}..$Aff|
|00000630| 69 6c 69 61 74 69 6f 6e | 7b 47 6c 61 73 67 6f 77 |iliation|{Glasgow|
|00000640| 20 52 6f 79 61 6c 20 49 | 6e 66 69 72 6d 61 72 79 | Royal I|nfirmary|
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|00000660| 65 64 20 4a 7d 0d 0a 24 | 56 6f 6c 75 6d 65 7b 32 |ed J}..$|Volume{2|
|00000670| 39 38 7d 0d 0a 24 50 61 | 67 65 7b 31 32 31 37 2d |98}..$Pa|ge{1217-|
|00000680| 31 32 32 30 7d 0d 0a 24 | 44 61 74 65 7b 4d 61 79 |1220}..$|Date{May|
|00000690| 20 36 2c 20 31 39 38 39 | 7d 0d 0a 24 59 42 56 6f | 6, 1989|}..$YBVo|
|000006a0| 6c 7b 31 39 39 30 20 59 | 65 61 72 20 42 6f 6f 6b |l{1990 Y|ear Book|
|000006b0| 20 6f 66 20 44 65 72 6d | 61 74 6f 6c 6f 67 79 7d | of Derm|atology}|
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|000006e0| 53 6f 62 65 72 20 61 6e | 64 20 46 69 74 7a 70 61 |Sober an|d Fitzpa|
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|00000700| 0d 0a 24 43 6f 6d 6d 65 | 6e 74 61 74 6f 72 7b 50 |..$Comme|ntator{P|
|00000710| 2e 45 2e 20 50 6f 63 68 | 69 2c 20 4d 2e 44 2e 7d |.E. Poch|i, M.D.}|
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|00000730| 29 20 59 65 61 72 62 6f | 6f 6b 20 4d 65 64 69 63 |) Yearbo|ok Medic|
|00000740| 61 6c 20 50 75 62 6c 69 | 73 68 65 72 73 2c 20 49 |al Publi|shers, I|
|00000750| 6e 63 2e 2c 20 31 39 39 | 30 0d 0a 0d 0a 31 39 39 |nc., 199|0....199|
|00000760| 30 20 59 65 61 72 20 42 | 6f 6f 6b 20 6f 66 20 44 |0 Year B|ook of D|
|00000770| 65 72 6d 61 74 6f 6c 6f | 67 79 20 28 52 29 0d 0a |ermatolo|gy (R)..|
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|00000790| 65 20 61 6e 64 20 52 65 | 6c 61 74 65 64 20 44 69 |e and Re|lated Di|
|000007a0| 73 6f 72 64 65 72 73 0d | 0a 0d 0a 2d 2d 2d 2d 2d |sorders.|...-----|
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|00000800| 69 6e 20 53 63 68 6f 6f | 6c 63 68 69 6c 64 72 65 |in Schoo|lchildre|
|00000810| 6e 3a 20 20 4e 6f 20 4c | 6f 6e 67 65 72 20 61 20 |n:  No L|onger a |
|00000820| 43 6f 6e 63 65 72 6e 20 | 66 6f 72 20 44 65 72 6d |Concern |for Derm|
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|00000870| 6c 20 49 6e 66 69 72 6d | 61 72 79 29 0d 0a 42 72 |l Infirm|ary)..Br|
|00000880| 20 4d 65 64 20 4a 20 32 | 39 38 3a 31 32 31 37 2d | Med J 2|98:1217-|
|00000890| 31 32 32 30 2c 20 4d 61 | 79 20 36 2c 20 31 39 38 |1220, Ma|y 6, 198|
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|00002c50| 69 73 73 75 65 73 20 61 | 72 65 20 64 65 73 65 72 |issues a|re deser|
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|00002d00| 4d 61 72 74 69 6e 2c 20 | 53 7d 0d 0a 24 41 66 66 |Martin, |S}..$Aff|
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|00002d70| 7b 39 32 31 2d 39 32 34 | 7d 0d 0a 24 44 61 74 65 |{921-924|}..$Date|
|00002d80| 7b 4a 75 6c 79 20 31 39 | 38 39 7d 0d 0a 24 59 42 |{July 19|89}..$YB|
|00002d90| 56 6f 6c 7b 31 39 39 30 | 20 59 65 61 72 20 42 6f |Vol{1990| Year Bo|
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|00002e00| 7b 50 2e 45 2e 20 50 6f | 63 68 69 2c 20 4d 2e 44 |{P.E. Po|chi, M.D|
|00002e10| 2e 7d 0d 0a 0d 0a 43 6f | 70 79 72 69 67 68 74 20 |.}....Co|pyright |
|00002e20| 28 63 29 20 59 65 61 72 | 62 6f 6f 6b 20 4d 65 64 |(c) Year|book Med|
|00002e30| 69 63 61 6c 20 50 75 62 | 6c 69 73 68 65 72 73 2c |ical Pub|lishers,|
|00002e40| 20 49 6e 63 2e 2c 20 31 | 39 39 30 0d 0a 0d 0a 31 | Inc., 1|990....1|
|00002e50| 39 39 30 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |990 Year| Book of|
|00002e60| 20 44 65 72 6d 61 74 6f | 6c 6f 67 79 20 28 52 29 | Dermato|logy (R)|
|00002e70| 0d 0a 0d 0a 43 68 61 70 | 74 65 72 20 31 2d 2d 41 |....Chap|ter 1--A|
|00002e80| 63 6e 65 20 61 6e 64 20 | 52 65 6c 61 74 65 64 20 |cne and |Related |
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|00002ea0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002eb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002ec0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002ed0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002ee0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 50 72 69 |--------|---..Pri|
|00002ef0| 6f 72 20 58 2d 52 61 79 | 20 54 68 65 72 61 70 79 |or X-Ray| Therapy|
|00002f00| 20 66 6f 72 20 41 63 6e | 65 20 52 65 6c 61 74 65 | for Acn|e Relate|
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|00002f30| 0d 0a 0d 0a 50 72 65 73 | 74 6f 6e 2d 4d 61 72 74 |....Pres|ton-Mart|
|00002f40| 69 6e 20 53 0d 0a 28 55 | 6e 69 76 20 6f 66 20 53 |in S..(U|niv of S|
|00002f50| 6f 75 74 68 65 72 6e 20 | 43 61 6c 69 66 6f 72 6e |outhern |Californ|
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|00002f70| 0d 0a 41 72 63 68 20 44 | 65 72 6d 61 74 6f 6c 20 |..Arch D|ermatol |
|00002f80| 31 32 35 3a 39 32 31 2d | 39 32 34 2c 20 4a 75 6c |125:921-|924, Jul|
|00002f90| 79 20 31 39 38 39 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |y 1989..|--------|
|00002fa0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002fb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002fc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002fd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002fe0| 2d 2d 2d 2d 2d 2d 0d 0a | 0d 0a 41 62 73 74 72 61 |------..|..Abstra|
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|00003c10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00003d20| 2c 20 31 39 38 39 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |, 1989..|--------|
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|00003d50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003d60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003d70| 2d 2d 2d 2d 2d 2d 0d 0a | 0d 0a 41 62 73 74 72 61 |------..|..Abstra|
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|00004430| 7a 65 6c 61 69 63 20 61 | 63 69 64 20 61 6e 64 20 |zelaic a|cid and |
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|00004840| 20 59 65 61 72 62 6f 6f | 6b 20 4d 65 64 69 63 61 | Yearboo|k Medica|
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|00004860| 63 2e 2c 20 31 39 39 30 | 0d 0a 0d 0a 31 39 39 30 |c., 1990|....1990|
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|00004890| 0a 43 68 61 70 74 65 72 | 20 31 2d 2d 41 63 6e 65 |.Chapter| 1--Acne|
|000048a0| 20 61 6e 64 20 52 65 6c | 61 74 65 64 20 44 69 73 | and Rel|ated Dis|
|000048b0| 6f 72 64 65 72 73 0d 0a | 0d 0a 2d 2d 2d 2d 2d 2d |orders..|..------|
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|000048d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000048e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000048f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004900| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 41 20 43 6f 6d 70 |--------|..A Comp|
|00004910| 61 72 61 74 69 76 65 20 | 53 74 75 64 79 20 6f 66 |arative |Study of|
|00004920| 20 42 65 6e 7a 6f 79 6c | 20 50 65 72 6f 78 69 64 | Benzoyl| Peroxid|
|00004930| 65 20 61 6e 64 20 43 6c | 69 6e 64 61 6d 79 63 69 |e and Cl|indamyci|
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|00004950| 54 72 65 61 74 69 6e 67 | 0d 0a 41 63 6e 65 20 56 |Treating|..Acne V|
|00004960| 75 6c 67 61 72 69 73 0d | 0a 0d 0a 53 77 69 6e 79 |ulgaris.|...Swiny|
|00004970| 65 72 20 4c 4a 3b 20 42 | 61 6b 65 72 20 4d 44 3b |er LJ; B|aker MD;|
|00004980| 20 53 77 69 6e 79 65 72 | 20 54 41 3b 20 4d 69 6c | Swinyer| TA; Mil|
|00004990| 6c 73 20 4f 48 20 4a 72 | 0d 0a 28 55 6e 69 76 20 |ls OH Jr|..(Univ |
|000049a0| 6f 66 20 55 74 61 68 3b | 20 4f 77 65 6e 20 4c 61 |of Utah;| Owen La|
|000049b0| 62 73 2c 20 46 6f 72 74 | 20 57 6f 72 74 68 2c 20 |bs, Fort| Worth, |
|000049c0| 54 65 78 3b 20 52 6f 62 | 65 72 74 20 57 6f 6f 64 |Tex; Rob|ert Wood|
|000049d0| 20 4a 6f 68 6e 73 6f 6e | 20 4d 65 64 20 53 63 68 | Johnson| Med Sch|
|000049e0| 6f 6f 6c 2c 20 4e 65 77 | 0d 0a 42 72 75 6e 73 77 |ool, New|..Brunsw|
|000049f0| 69 63 6b 2c 20 4e 4a 29 | 0d 0a 42 72 20 4a 20 44 |ick, NJ)|..Br J D|
|00004a00| 65 72 6d 61 74 6f 6c 20 | 31 31 39 3a 36 31 35 2d |ermatol |119:615-|
|00004a10| 36 32 32 2c 20 4e 6f 76 | 65 6d 62 65 72 20 31 39 |622, Nov|ember 19|
|00004a20| 38 38 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |88..----|--------|
|00004a30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004a40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004a50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004a60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004aa0| 65 72 6f 78 69 64 65 20 | 77 61 73 20 63 6f 6d 70 |eroxide |was comp|
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|00005140| 64 75 63 74 69 6f 6e 2e | 0d 0a 43 6c 69 6e 64 61 |duction.|..Clinda|
|00005150| 6d 79 63 69 6e 20 70 68 | 6f 73 70 68 61 74 65 20 |mycin ph|osphate |
|00005160| 68 61 64 20 61 20 6d 69 | 6c 64 65 72 20 65 66 66 |had a mi|lder eff|
|00005170| 65 63 74 20 6f 6e 20 74 | 68 65 20 73 6b 69 6e 20 |ect on t|he skin |
|00005180| 73 75 72 66 61 63 65 2e | 0d 0a 0d 0a 50 6f 73 74 |surface.|....Post|
|00005190| 2d 43 6f 6d 6d 65 6e 74 | 0d 0a 0d 0a 20 20 20 20 |-Comment|....    |
|000051a0| 20 54 68 65 20 6f 75 74 | 63 6f 6d 65 20 6f 66 20 | The out|come of |
|000051b0| 74 68 69 73 20 73 74 75 | 64 79 20 73 70 65 61 6b |this stu|dy speak|
|000051c0| 73 20 66 6f 72 20 69 74 | 73 65 6c 66 2e 20 20 49 |s for it|self.  I|
|000051d0| 6e 20 74 68 65 20 61 72 | 74 69 63 6c 65 27 73 0d |n the ar|ticle's.|
|000051e0| 0a 69 6e 74 72 6f 64 75 | 63 74 69 6f 6e 2c 20 74 |.introdu|ction, t|
|000051f0| 68 65 20 61 75 74 68 6f | 72 73 20 6d 61 6b 65 20 |he autho|rs make |
|00005200| 6e 6f 74 65 20 6f 66 20 | 61 20 70 6c 65 74 68 6f |note of |a pletho|
|00005210| 72 61 20 6f 66 20 72 65 | 70 6f 72 74 73 20 6f 6e |ra of re|ports on|
|00005220| 20 74 68 65 20 65 66 66 | 65 63 74 20 6f 66 0d 0a | the eff|ect of..|
|00005230| 62 65 6e 7a 6f 79 6c 20 | 70 65 72 6f 78 69 64 65 |benzoyl |peroxide|
|00005240| 20 61 6e 64 20 74 6f 70 | 69 63 61 6c 20 61 6e 74 | and top|ical ant|
|00005250| 69 62 69 6f 74 69 63 73 | 20 69 6e 20 61 63 6e 65 |ibiotics| in acne|
|00005260| 2e 20 20 42 75 74 20 70 | 72 6f 62 61 62 6c 79 20 |.  But p|robably |
|00005270| 6e 6f 6e 65 20 61 6d 6f | 6e 67 0d 0a 74 68 65 6d |none amo|ng..them|
|00005280| 20 69 6e 63 6c 75 64 65 | 20 61 20 73 74 75 64 79 | include| a study|
|00005290| 20 6f 66 20 70 61 74 69 | 65 6e 74 73 20 75 73 69 | of pati|ents usi|
|000052a0| 6e 67 20 62 6f 74 68 20 | 62 65 6e 7a 6f 79 6c 20 |ng both |benzoyl |
|000052b0| 70 65 72 6f 78 69 64 65 | 20 61 6e 64 20 63 6c 69 |peroxide| and cli|
|000052c0| 6e 64 61 6d 79 63 69 6e | 0d 0a 70 68 6f 73 70 68 |ndamycin|..phosph|
|000052d0| 61 74 65 2c 20 73 6f 6d | 65 74 68 69 6e 67 20 74 |ate, som|ething t|
|000052e0| 68 61 74 20 69 73 20 73 | 75 72 65 6c 79 20 64 6f |hat is s|urely do|
|000052f0| 6e 65 20 66 72 65 71 75 | 65 6e 74 6c 79 20 69 6e |ne frequ|ently in|
|00005300| 20 63 6c 69 6e 69 63 61 | 6c 20 70 72 61 63 74 69 | clinica|l practi|
|00005310| 63 65 2c 0d 0a 70 61 72 | 74 69 63 75 6c 61 72 6c |ce,..par|ticularl|
|00005320| 79 20 77 68 65 6e 20 6f | 6e 65 20 63 6f 6e 73 69 |y when o|ne consi|
|00005330| 64 65 72 73 20 74 68 61 | 74 20 74 68 65 20 6d 65 |ders tha|t the me|
|00005340| 63 68 61 6e 69 73 6d 20 | 6f 66 20 74 68 65 20 61 |chanism |of the a|
|00005350| 6e 74 69 62 61 63 74 65 | 72 69 61 6c 20 61 63 74 |ntibacte|rial act|
|00005360| 69 6f 6e 0d 0a 6f 66 20 | 65 61 63 68 20 64 72 75 |ion..of |each dru|
|00005370| 67 20 69 73 20 64 69 66 | 66 65 72 65 6e 74 2e 2d |g is dif|ferent.-|
|00005380| 2d 50 2e 45 2e 20 50 6f | 63 68 69 2c 20 4d 2e 44 |-P.E. Po|chi, M.D|
|00005390| 2e 0d 0a 24 55 6e 69 71 | 75 65 5f 49 44 7b 59 52 |...$Uniq|ue_ID{YR|
|000053a0| 42 30 39 30 30 36 7d 0d | 0a 24 54 69 74 6c 65 7b |B09006}.|.$Title{|
|000053b0| 41 20 44 6f 75 62 6c 65 | 2d 42 6c 69 6e 64 20 43 |A Double|-Blind C|
|000053c0| 6c 69 6e 69 63 61 6c 20 | 54 72 69 61 6c 20 57 69 |linical |Trial Wi|
|000053d0| 74 68 20 61 20 4c 6f 74 | 69 6f 6e 20 43 6f 6e 74 |th a Lot|ion Cont|
|000053e0| 61 69 6e 69 6e 67 20 35 | 25 20 42 65 6e 7a 6f 79 |aining 5|% Benzoy|
|000053f0| 6c 20 50 65 72 6f 78 69 | 64 65 20 61 6e 64 20 32 |l Peroxi|de and 2|
|00005400| 25 20 4d 69 63 6f 6e 61 | 7a 6f 6c 65 20 69 6e 20 |% Micona|zole in |
|00005410| 50 61 74 69 65 6e 74 73 | 20 57 69 74 68 20 41 63 |Patients| With Ac|
|00005420| 6e 65 20 56 75 6c 67 61 | 72 69 73 7d 0d 0a 24 41 |ne Vulga|ris}..$A|
|00005430| 75 74 68 6f 72 7b 4d 65 | 73 71 75 69 74 61 2d 47 |uthor{Me|squita-G|
|00005440| 75 69 6d 61 72 61 65 73 | 2c 20 4a 0d 0a 52 61 6d |uimaraes|, J..Ram|
|00005450| 6f 73 2c 20 53 0d 0a 54 | 61 76 61 72 65 73 2c 20 |os, S..T|avares, |
|00005460| 4d 52 0d 0a 43 61 72 76 | 61 6c 68 6f 2c 20 4d 52 |MR..Carv|alho, MR|
|00005470| 7d 0d 0a 24 41 66 66 69 | 6c 69 61 74 69 6f 6e 7b |}..$Affi|liation{|
|00005480| 46 61 63 75 6c 74 79 20 | 6f 66 20 4d 65 64 69 63 |Faculty |of Medic|
|00005490| 69 6e 65 20 61 6e 64 20 | 48 6f 73 70 20 53 20 4a |ine and |Hosp S J|
|000054a0| 6f 61 6f 2c 20 50 6f 72 | 74 6f 2c 20 50 6f 72 74 |oao, Por|to, Port|
|000054b0| 75 67 61 6c 7d 0d 0a 24 | 4a 6f 75 72 6e 61 6c 7b |ugal}..$|Journal{|
|000054c0| 43 6c 69 6e 20 45 78 70 | 20 44 65 72 6d 61 74 6f |Clin Exp| Dermato|
|000054d0| 6c 7d 0d 0a 24 56 6f 6c | 75 6d 65 7b 31 34 7d 0d |l}..$Vol|ume{14}.|
|000054e0| 0a 24 50 61 67 65 7b 33 | 35 37 2d 33 36 30 7d 0d |.$Page{3|57-360}.|
|000054f0| 0a 24 44 61 74 65 7b 53 | 65 70 74 65 6d 62 65 72 |.$Date{S|eptember|
|00005500| 20 31 39 38 39 7d 0d 0a | 24 59 42 56 6f 6c 7b 31 | 1989}..|$YBVol{1|
|00005510| 39 39 30 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |990 Year| Book of|
|00005520| 20 44 65 72 6d 61 74 6f | 6c 6f 67 79 7d 0d 0a 24 | Dermato|logy}..$|
|00005530| 43 68 61 70 74 65 72 7b | 31 2d 37 7d 0d 0a 24 59 |Chapter{|1-7}..$Y|
|00005540| 42 45 64 69 74 6f 72 7b | 44 72 73 2e 20 53 6f 62 |BEditor{|Drs. Sob|
|00005550| 65 72 20 61 6e 64 20 46 | 69 74 7a 70 61 74 72 69 |er and F|itzpatri|
|00005560| 63 6b 7d 0d 0a 24 54 61 | 62 6c 65 7b 7d 0d 0a 24 |ck}..$Ta|ble{}..$|
|00005570| 43 6f 6d 6d 65 6e 74 61 | 74 6f 72 7b 50 2e 45 2e |Commenta|tor{P.E.|
|00005580| 20 50 6f 63 68 69 2c 20 | 4d 2e 44 2e 7d 0d 0a 0d | Pochi, |M.D.}...|
|00005590| 0a 43 6f 70 79 72 69 67 | 68 74 20 28 63 29 20 59 |.Copyrig|ht (c) Y|
|000055a0| 65 61 72 62 6f 6f 6b 20 | 4d 65 64 69 63 61 6c 20 |earbook |Medical |
|000055b0| 50 75 62 6c 69 73 68 65 | 72 73 2c 20 49 6e 63 2e |Publishe|rs, Inc.|
|000055c0| 2c 20 31 39 39 30 0d 0a | 0d 0a 31 39 39 30 20 59 |, 1990..|..1990 Y|
|000055d0| 65 61 72 20 42 6f 6f 6b | 20 6f 66 20 44 65 72 6d |ear Book| of Derm|
|000055e0| 61 74 6f 6c 6f 67 79 20 | 28 52 29 0d 0a 0d 0a 43 |atology |(R)....C|
|000055f0| 68 61 70 74 65 72 20 31 | 2d 2d 41 63 6e 65 20 61 |hapter 1|--Acne a|
|00005600| 6e 64 20 52 65 6c 61 74 | 65 64 20 44 69 73 6f 72 |nd Relat|ed Disor|
|00005610| 64 65 72 73 0d 0a 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |ders....|--------|
|00005620| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005630| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005640| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005650| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005660| 2d 2d 2d 2d 2d 2d 0d 0a | 41 20 44 6f 75 62 6c 65 |------..|A Double|
|00005670| 2d 42 6c 69 6e 64 20 43 | 6c 69 6e 69 63 61 6c 20 |-Blind C|linical |
|00005680| 54 72 69 61 6c 20 57 69 | 74 68 20 61 20 4c 6f 74 |Trial Wi|th a Lot|
|00005690| 69 6f 6e 20 43 6f 6e 74 | 61 69 6e 69 6e 67 20 35 |ion Cont|aining 5|
|000056a0| 25 20 42 65 6e 7a 6f 79 | 6c 20 50 65 72 6f 78 69 |% Benzoy|l Peroxi|
|000056b0| 64 65 20 61 6e 64 0d 0a | 32 25 20 4d 69 63 6f 6e |de and..|2% Micon|
|000056c0| 61 7a 6f 6c 65 20 69 6e | 20 50 61 74 69 65 6e 74 |azole in| Patient|
|000056d0| 73 20 57 69 74 68 20 41 | 63 6e 65 20 56 75 6c 67 |s With A|cne Vulg|
|000056e0| 61 72 69 73 0d 0a 0d 0a | 4d 65 73 71 75 69 74 61 |aris....|Mesquita|
|000056f0| 2d 47 75 69 6d 61 72 61 | 65 73 20 4a 3b 20 52 61 |-Guimara|es J; Ra|
|00005700| 6d 6f 73 20 53 3b 20 54 | 61 76 61 72 65 73 20 4d |mos S; T|avares M|
|00005710| 52 3b 20 43 61 72 76 61 | 6c 68 6f 20 4d 52 0d 0a |R; Carva|lho MR..|
|00005720| 28 46 61 63 75 6c 74 79 | 20 6f 66 20 4d 65 64 69 |(Faculty| of Medi|
|00005730| 63 69 6e 65 20 61 6e 64 | 20 48 6f 73 70 20 53 20 |cine and| Hosp S |
|00005740| 4a 6f 61 6f 2c 20 50 6f | 72 74 6f 2c 20 50 6f 72 |Joao, Po|rto, Por|
|00005750| 74 75 67 61 6c 29 0d 0a | 43 6c 69 6e 20 45 78 70 |tugal)..|Clin Exp|
|00005760| 20 44 65 72 6d 61 74 6f | 6c 20 31 34 3a 33 35 37 | Dermato|l 14:357|
|00005770| 2d 33 36 30 2c 20 53 65 | 70 74 65 6d 62 65 72 20 |-360, Se|ptember |
|00005780| 31 39 38 39 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |1989..--|--------|
|00005790| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000057a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000057b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000057c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000057d0| 2d 2d 2d 2d 0d 0a 0d 0a | 41 62 73 74 72 61 63 74 |----....|Abstract|
|000057e0| 0d 0a 0d 0a 20 20 20 20 | 20 42 6f 74 68 20 62 65 |....    | Both be|
|000057f0| 6e 7a 6f 79 6c 20 70 65 | 72 6f 78 69 64 65 20 61 |nzoyl pe|roxide a|
|00005800| 6c 6f 6e 65 20 61 6e 64 | 20 61 20 6d 69 63 6f 6e |lone and| a micon|
|00005810| 61 7a 6f 6c 65 2d 62 65 | 6e 7a 6f 79 6c 20 70 65 |azole-be|nzoyl pe|
|00005820| 72 6f 78 69 64 65 20 63 | 6f 6d 62 69 6e 61 74 69 |roxide c|ombinati|
|00005830| 6f 6e 0d 0a 61 70 70 6c | 69 65 64 20 74 6f 70 69 |on..appl|ied topi|
|00005840| 63 61 6c 6c 79 20 61 72 | 65 20 65 66 66 65 63 74 |cally ar|e effect|
|00005850| 69 76 65 20 61 67 61 69 | 6e 73 74 20 61 63 6e 65 |ive agai|nst acne|
|00005860| 20 76 75 6c 67 61 72 69 | 73 2e 20 20 49 6e 20 61 | vulgari|s.  In a|
|00005870| 20 63 6f 6e 74 72 6f 6c | 6c 65 64 2c 0d 0a 72 61 | control|led,..ra|
|00005880| 6e 64 6f 6d 69 7a 65 64 | 2c 20 64 6f 75 62 6c 65 |ndomized|, double|
|00005890| 2d 62 6c 69 6e 64 20 73 | 74 75 64 79 20 74 68 65 |-blind s|tudy the|
|000058a0| 20 65 66 66 65 63 74 69 | 76 65 6e 65 73 73 20 6f | effecti|veness o|
|000058b0| 66 20 61 20 6c 6f 74 69 | 6f 6e 20 63 6f 6e 74 61 |f a loti|on conta|
|000058c0| 69 6e 69 6e 67 20 35 25 | 0d 0a 62 65 6e 7a 6f 79 |ining 5%|..benzoy|
|000058d0| 6c 20 70 65 72 6f 78 69 | 64 65 20 61 6e 64 20 32 |l peroxi|de and 2|
|000058e0| 25 20 6d 69 63 6f 6e 61 | 7a 6f 6c 65 20 77 61 73 |% micona|zole was|
|000058f0| 20 63 6f 6d 70 61 72 65 | 64 20 77 69 74 68 20 74 | compare|d with t|
|00005900| 68 61 74 20 6f 66 20 61 | 20 63 6f 6e 74 72 6f 6c |hat of a| control|
|00005910| 0d 0a 70 72 65 70 61 72 | 61 74 69 6f 6e 20 63 6f |..prepar|ation co|
|00005920| 6e 74 61 69 6e 69 6e 67 | 20 6f 6e 6c 79 20 32 25 |ntaining| only 2%|
|00005930| 20 62 65 6e 7a 6f 79 6c | 20 70 65 72 6f 78 69 64 | benzoyl| peroxid|
|00005940| 65 20 69 6e 20 70 61 74 | 69 65 6e 74 73 20 77 69 |e in pat|ients wi|
|00005950| 74 68 20 69 6e 66 6c 61 | 6d 6d 61 74 6f 72 79 0d |th infla|mmatory.|
|00005960| 0a 6f 72 20 63 6f 6d 65 | 64 6f 6e 61 6c 20 61 63 |.or come|donal ac|
|00005970| 6e 65 2e 20 20 54 68 65 | 20 6c 6f 74 69 6f 6e 73 |ne.  The| lotions|
|00005980| 20 77 65 72 65 20 61 70 | 70 6c 69 65 64 20 6f 6e | were ap|plied on|
|00005990| 63 65 20 61 20 64 61 79 | 20 66 6f 72 20 74 68 65 |ce a day| for the|
|000059a0| 20 66 69 72 73 74 20 77 | 65 65 6b 20 61 6e 64 0d | first w|eek and.|
|000059b0| 0a 74 68 65 6e 20 74 77 | 69 63 65 20 64 61 69 6c |.then tw|ice dail|
|000059c0| 79 20 74 68 72 6f 75 67 | 68 20 64 61 79 20 34 35 |y throug|h day 45|
|000059d0| 2e 0d 0a 20 20 20 20 20 | 54 68 65 20 32 20 6c 6f |...     |The 2 lo|
|000059e0| 74 69 6f 6e 73 20 68 61 | 64 20 73 69 6d 69 6c 61 |tions ha|d simila|
|000059f0| 72 20 65 66 66 65 63 74 | 73 20 69 6e 20 70 61 74 |r effect|s in pat|
|00005a00| 69 65 6e 74 73 20 77 69 | 74 68 20 63 6f 6d 65 64 |ients wi|th comed|
|00005a10| 6f 6e 61 6c 20 61 63 6e | 65 2e 20 20 49 6e 0d 0a |onal acn|e.  In..|
|00005a20| 70 61 74 69 65 6e 74 73 | 20 77 69 74 68 20 69 6e |patients| with in|
|00005a30| 66 6c 61 6d 6d 61 74 6f | 72 79 20 61 63 6e 65 2c |flammato|ry acne,|
|00005a40| 20 74 68 65 20 63 6f 6d | 62 69 6e 61 74 69 6f 6e | the com|bination|
|00005a50| 20 6c 6f 74 69 6f 6e 20 | 77 61 73 20 73 69 67 6e | lotion |was sign|
|00005a60| 69 66 69 63 61 6e 74 6c | 79 20 6d 6f 72 65 0d 0a |ificantl|y more..|
|00005a70| 65 66 66 65 63 74 69 76 | 65 20 61 74 20 64 61 79 |effectiv|e at day|
|00005a80| 20 33 30 2c 20 77 69 74 | 68 20 61 20 36 36 25 20 | 30, wit|h a 66% |
|00005a90| 72 65 64 75 63 74 69 6f | 6e 20 69 6e 20 6e 75 6d |reductio|n in num|
|00005aa0| 62 65 72 20 6f 66 20 6c | 65 73 69 6f 6e 73 2c 20 |ber of l|esions, |
|00005ab0| 74 68 61 6e 20 74 68 65 | 0d 0a 73 69 6e 67 6c 65 |than the|..single|
|00005ac0| 2d 69 6e 67 72 65 64 69 | 65 6e 74 20 6c 6f 74 69 |-ingredi|ent loti|
|00005ad0| 6f 6e 2c 20 77 69 74 68 | 20 77 68 69 63 68 20 74 |on, with| which t|
|00005ae0| 68 65 20 72 65 64 75 63 | 74 69 6f 6e 20 77 61 73 |he reduc|tion was|
|00005af0| 20 33 37 25 2e 20 20 41 | 20 64 69 66 66 65 72 65 | 37%.  A| differe|
|00005b00| 6e 63 65 0d 0a 72 65 6d | 61 69 6e 65 64 20 61 74 |nce..rem|ained at|
|00005b10| 20 64 61 79 20 34 35 2c | 20 62 75 74 20 69 74 20 | day 45,| but it |
|00005b20| 77 61 73 20 6e 6f 20 6c | 6f 6e 67 65 72 20 73 69 |was no l|onger si|
|00005b30| 67 6e 69 66 69 63 61 6e | 74 2e 20 20 41 64 76 65 |gnifican|t.  Adve|
|00005b40| 72 73 65 20 65 66 66 65 | 63 74 73 2c 0d 0a 69 6e |rse effe|cts,..in|
|00005b50| 63 6c 75 64 69 6e 67 20 | 65 72 79 74 68 65 6d 61 |cluding |erythema|
|00005b60| 2c 20 69 74 63 68 69 6e | 67 2c 20 61 6e 64 20 6d |, itchin|g, and m|
|00005b70| 6f 64 65 72 61 74 65 20 | 65 78 66 6f 6c 69 61 74 |oderate |exfoliat|
|00005b80| 69 6f 6e 2c 20 77 65 72 | 65 20 73 69 6d 69 6c 61 |ion, wer|e simila|
|00005b90| 72 20 77 69 74 68 20 62 | 6f 74 68 0d 0a 72 65 67 |r with b|oth..reg|
|00005ba0| 69 6d 65 6e 73 2e 0d 0a | 20 20 20 20 20 54 68 65 |imens...|     The|
|00005bb0| 73 65 20 72 65 73 75 6c | 74 73 20 73 75 67 67 65 |se resul|ts sugge|
|00005bc0| 73 74 20 74 68 61 74 20 | 63 6f 6d 62 69 6e 61 74 |st that |combinat|
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|00005bf0| 72 6f 6c 65 0d 0a 69 6e | 20 61 63 6e 65 20 76 75 |role..in| acne vu|
|00005c00| 6c 67 61 72 69 73 2e 20 | 20 49 6d 69 64 61 7a 6f |lgaris. | Imidazo|
|00005c10| 6c 65 20 63 6f 6d 70 6f | 75 6e 64 73 20 72 65 64 |le compo|unds red|
|00005c20| 75 63 65 20 6c 69 70 61 | 73 65 20 61 63 74 69 76 |uce lipa|se activ|
|00005c30| 69 74 79 20 61 6e 64 20 | 61 63 74 20 61 67 61 69 |ity and |act agai|
|00005c40| 6e 73 74 0d 0a 50 72 6f | 70 69 6f 6e 69 62 61 63 |nst..Pro|pionibac|
|00005c50| 74 65 72 69 75 6d 20 61 | 63 6e 65 73 20 61 6e 64 |terium a|cnes and|
|00005c60| 20 53 74 61 70 68 79 6c | 6f 63 6f 63 63 75 73 20 | Staphyl|ococcus |
|00005c70| 6f 72 67 61 6e 69 73 6d | 73 20 69 6e 20 76 69 74 |organism|s in vit|
|00005c80| 72 6f 2e 20 20 41 20 73 | 79 6e 65 72 67 69 73 74 |ro.  A s|ynergist|
|00005c90| 69 63 0d 0a 65 66 66 65 | 63 74 20 68 61 73 20 62 |ic..effe|ct has b|
|00005ca0| 65 65 6e 20 72 65 70 6f | 72 74 65 64 20 77 68 65 |een repo|rted whe|
|00005cb0| 6e 20 62 65 6e 7a 6f 79 | 6c 20 70 65 72 6f 78 69 |n benzoy|l peroxi|
|00005cc0| 64 65 20 61 6e 64 20 6d | 69 63 6f 6e 61 7a 6f 6c |de and m|iconazol|
|00005cd0| 65 20 61 72 65 20 75 73 | 65 64 0d 0a 74 6f 67 65 |e are us|ed..toge|
|00005ce0| 74 68 65 72 2e 0d 0a 0d | 0a 50 6f 73 74 2d 43 6f |ther....|.Post-Co|
|00005cf0| 6d 6d 65 6e 74 0d 0a 0d | 0a 20 20 20 20 20 54 68 |mment...|.     Th|
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|00005d20| 6e 6f 74 20 74 68 65 20 | 6c 61 73 74 2c 20 61 72 |not the |last, ar|
|00005d30| 74 69 63 6c 65 20 74 6f | 20 62 65 20 70 75 62 6c |ticle to| be publ|
|00005d40| 69 73 68 65 64 0d 0a 6f | 6e 20 74 68 65 20 62 65 |ished..o|n the be|
|00005d50| 6e 7a 6f 79 6c 20 70 65 | 72 6f 78 69 64 65 2d 6d |nzoyl pe|roxide-m|
|00005d60| 69 63 6f 6e 61 7a 6f 6c | 65 20 74 72 65 61 74 6d |iconazol|e treatm|
|00005d70| 65 6e 74 20 6f 66 20 61 | 63 6e 65 2e 20 20 53 65 |ent of a|cne.  Se|
|00005d80| 76 65 72 61 6c 20 70 72 | 65 76 69 6f 75 73 6c 79 |veral pr|eviously|
|00005d90| 0d 0a 70 75 62 6c 69 73 | 68 65 64 20 73 74 75 64 |..publis|hed stud|
|00005da0| 69 65 73 20 68 61 76 65 | 20 73 69 6d 69 6c 61 72 |ies have| similar|
|00005db0| 6c 79 20 70 75 72 70 6f | 72 74 65 64 20 74 6f 20 |ly purpo|rted to |
|00005dc0| 73 68 6f 77 20 74 68 61 | 74 20 74 68 65 20 63 6f |show tha|t the co|
|00005dd0| 6d 62 69 6e 61 74 69 6f | 6e 20 69 73 0d 0a 73 75 |mbinatio|n is..su|
|00005de0| 70 65 72 69 6f 72 20 74 | 6f 20 62 65 6e 7a 6f 79 |perior t|o benzoy|
|00005df0| 6c 20 70 65 72 6f 78 69 | 64 65 20 61 6c 6f 6e 65 |l peroxi|de alone|
|00005e00| 2c 20 62 75 74 20 6e 6f | 74 20 76 65 72 79 20 63 |, but no|t very c|
|00005e10| 6f 6e 76 69 6e 63 69 6e | 67 6c 79 20 73 6f 2e 20 |onvincin|gly so. |
|00005e20| 20 41 6c 74 68 6f 75 67 | 68 0d 0a 74 68 69 73 20 | Althoug|h..this |
|00005e30| 77 61 73 20 61 20 64 6f | 75 62 6c 65 2d 62 6c 69 |was a do|uble-bli|
|00005e40| 6e 64 20 63 6f 6e 74 72 | 6f 6c 6c 65 64 20 73 74 |nd contr|olled st|
|00005e50| 75 64 79 2c 20 6f 6e 6c | 79 20 31 35 20 61 63 6e |udy, onl|y 15 acn|
|00005e60| 65 20 70 61 74 69 65 6e | 74 73 20 63 6f 6d 70 72 |e patien|ts compr|
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|00005f20| 20 34 35 20 64 61 79 73 | 20 72 61 69 73 65 73 20 | 45 days| raises |
|00005f30| 73 65 72 69 6f 75 73 20 | 71 75 65 73 74 69 6f 6e |serious |question|
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|00005fb0| 74 61 6e 74 20 50 72 6f | 70 69 6f 6e 69 62 61 63 |tant Pro|pionibac|
|00005fc0| 74 65 72 69 61 20 69 6e | 20 41 6e 74 69 62 69 6f |teria in| Antibio|
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|00006050| 6c 69 61 74 69 6f 6e 7b | 55 6e 69 76 20 6f 66 20 |liation{|Univ of |
|00006060| 4c 65 65 64 73 3b 20 4c | 65 65 64 73 20 47 65 6e |Leeds; L|eeds Gen|
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|00006080| 61 6e 64 7d 0d 0a 24 4a | 6f 75 72 6e 61 6c 7b 42 |and}..$J|ournal{B|
|00006090| 72 20 4a 20 44 65 72 6d | 61 74 6f 6c 7d 0d 0a 24 |r J Derm|atol}..$|
|000060a0| 56 6f 6c 75 6d 65 7b 31 | 32 31 7d 0d 0a 24 50 61 |Volume{1|21}..$Pa|
|000060b0| 67 65 7b 35 31 2d 35 37 | 7d 0d 0a 24 44 61 74 65 |ge{51-57|}..$Date|
|000060c0| 7b 4a 75 6c 79 20 31 39 | 38 39 7d 0d 0a 24 59 42 |{July 19|89}..$YB|
|000060d0| 56 6f 6c 7b 31 39 39 30 | 20 59 65 61 72 20 42 6f |Vol{1990| Year Bo|
|000060e0| 6f 6b 20 6f 66 20 44 65 | 72 6d 61 74 6f 6c 6f 67 |ok of De|rmatolog|
|000060f0| 79 7d 0d 0a 24 43 68 61 | 70 74 65 72 7b 31 2d 38 |y}..$Cha|pter{1-8|
|00006100| 7d 0d 0a 24 59 42 45 64 | 69 74 6f 72 7b 44 72 73 |}..$YBEd|itor{Drs|
|00006110| 2e 20 53 6f 62 65 72 20 | 61 6e 64 20 46 69 74 7a |. Sober |and Fitz|
|00006120| 70 61 74 72 69 63 6b 7d | 0d 0a 24 54 61 62 6c 65 |patrick}|..$Table|
|00006130| 7b 7d 0d 0a 24 43 6f 6d | 6d 65 6e 74 61 74 6f 72 |{}..$Com|mentator|
|00006140| 7b 50 2e 45 2e 20 50 6f | 63 68 69 2c 20 4d 2e 44 |{P.E. Po|chi, M.D|
|00006150| 2e 7d 0d 0a 0d 0a 43 6f | 70 79 72 69 67 68 74 20 |.}....Co|pyright |
|00006160| 28 63 29 20 59 65 61 72 | 62 6f 6f 6b 20 4d 65 64 |(c) Year|book Med|
|00006170| 69 63 61 6c 20 50 75 62 | 6c 69 73 68 65 72 73 2c |ical Pub|lishers,|
|00006180| 20 49 6e 63 2e 2c 20 31 | 39 39 30 0d 0a 0d 0a 31 | Inc., 1|990....1|
|00006190| 39 39 30 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |990 Year| Book of|
|000061a0| 20 44 65 72 6d 61 74 6f | 6c 6f 67 79 20 28 52 29 | Dermato|logy (R)|
|000061b0| 0d 0a 0d 0a 43 68 61 70 | 74 65 72 20 31 2d 2d 41 |....Chap|ter 1--A|
|000061c0| 63 6e 65 20 61 6e 64 20 | 52 65 6c 61 74 65 64 20 |cne and |Related |
|000061d0| 44 69 73 6f 72 64 65 72 | 73 0d 0a 0d 0a 2d 2d 2d |Disorder|s....---|
|000061e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000061f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006200| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006210| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006220| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 45 72 79 |--------|---..Ery|
|00006230| 74 68 72 6f 6d 79 63 69 | 6e 20 52 65 73 69 73 74 |thromyci|n Resist|
|00006240| 61 6e 74 20 50 72 6f 70 | 69 6f 6e 69 62 61 63 74 |ant Prop|ionibact|
|00006250| 65 72 69 61 20 69 6e 20 | 41 6e 74 69 62 69 6f 74 |eria in |Antibiot|
|00006260| 69 63 20 54 72 65 61 74 | 65 64 20 41 63 6e 65 20 |ic Treat|ed Acne |
|00006270| 70 61 74 69 65 6e 74 73 | 3a 0d 0a 41 73 73 6f 63 |patients|:..Assoc|
|00006280| 69 61 74 69 6f 6e 20 57 | 69 74 68 20 54 68 65 72 |iation W|ith Ther|
|00006290| 61 70 65 75 74 69 63 20 | 46 61 69 6c 75 72 65 0d |apeutic |Failure.|
|000062a0| 0a 0d 0a 45 61 64 79 20 | 45 41 3b 20 43 6f 76 65 |...Eady |EA; Cove|
|000062b0| 20 4a 48 3b 20 48 6f 6c | 6c 61 6e 64 20 4b 54 3b | JH; Hol|land KT;|
|000062c0| 20 43 75 6e 6c 69 66 66 | 65 20 57 4a 0d 0a 28 55 | Cunliff|e WJ..(U|
|000062d0| 6e 69 76 20 6f 66 20 4c | 65 65 64 73 3b 20 4c 65 |niv of L|eeds; Le|
|000062e0| 65 64 73 20 47 65 6e 20 | 49 6e 66 69 72 6d 61 72 |eds Gen |Infirmar|
|000062f0| 79 2c 20 45 6e 67 6c 61 | 6e 64 29 0d 0a 42 72 20 |y, Engla|nd)..Br |
|00006300| 4a 20 44 65 72 6d 61 74 | 6f 6c 20 31 32 31 3a 35 |J Dermat|ol 121:5|
|00006310| 31 2d 35 37 2c 20 4a 75 | 6c 79 20 31 39 38 39 0d |1-57, Ju|ly 1989.|
|00006320| 0a 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |.-------|--------|
|00006330| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006340| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006350| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006360| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 0d |--------|-------.|
|00006370| 0a 0d 0a 41 62 73 74 72 | 61 63 74 0d 0a 0d 0a 20 |...Abstr|act.... |
|00006380| 20 20 20 20 45 72 79 74 | 68 72 6f 6d 79 63 69 6e |    Eryt|hromycin|
|00006390| 20 69 73 20 61 20 73 65 | 63 6f 6e 64 2d 6c 69 6e | is a se|cond-lin|
|000063a0| 65 20 64 72 75 67 20 66 | 6f 72 20 75 73 65 20 69 |e drug f|or use i|
|000063b0| 6e 20 70 61 74 69 65 6e | 74 73 20 77 69 74 68 20 |n patien|ts with |
|000063c0| 61 63 6e 65 20 77 68 6f | 20 66 61 69 6c 0d 0a 74 |acne who| fail..t|
|000063d0| 6f 20 72 65 73 70 6f 6e | 64 20 74 6f 20 74 65 74 |o respon|d to tet|
|000063e0| 72 61 63 79 63 6c 69 6e | 65 20 74 68 65 72 61 70 |racyclin|e therap|
|000063f0| 79 2c 20 62 75 74 20 72 | 65 73 69 73 74 61 6e 74 |y, but r|esistant|
+--------+-------------------------+-------------------------+--------+--------+